Examination of the Circle Spline Routine

The Circle Spline routine is currently being used for generating both two and three dimensional spline curves. It was developed for use in ESCHER, a mesh generating routine written to provide a computationally simple and efficient method for building meshes along curved surfaces. Circle Spline is a parametric linear blending spline. Because many computerized machining operations involve circular shapes, the Circle Spline is well suited for both the design and manufacturing processes and shows promise as an alternative to the spline methods currently supported by the Initial Graphics Specification (IGES)

UHE neutrino searches using a Lunar target: First Results from the RESUN search

During the past decade there have been several attempts to detect cosmogenic ultra high energy (UHE) neutrinos by searching for radio Cerenkov bursts resulting from charged impact showers in terrestrial ice or the lunar regolith. So far these radio searches have yielded no detections, but the inferred flux upper limits have started to constrain physical models for UHE neutrino generation. For searches which use the Moon as a target, we summarize the physics of the interaction, properties of the resulting Cerenkov radio pulse, detection statistics, effective aperture scaling laws, and derivation of upper limits for isotropic and point source models. We report on initial results from the RESUN search, which uses the Expanded Very Large Array configured in multiple sub-arrays of four antennas at 1.45 GHz pointing along the lunar limb. We detected no pulses of lunar origin during 45 observing hours. This implies upper limits to the differential neutrino flux E^2 dN/dE < 0.003 EeV km^{-2} s^{-1} sr^{-1} and < 0.0003 EeV km$^{-2} s^{-1} at 90% confidence level for isotropic and sampled point sources respectively, in the neutrino energy range 10^{21.6} < E(eV) < 10^{22.6}. The isotropic flux limit is comparable to the lowest published upper limits for lunar searches. The full RESUN search, with an additional 200 hours observing time and an improved data acquisition scheme, will be be an order of magnitude more sensitive in the energy range 10^{21} < E(eV) < 10^{22} than previous lunar-target searches, and will test Z burst models of neutrino generation.Comment: 26 pages, 14 figure

Large phenotype jumps in biomolecular evolution

By defining the phenotype of a biopolymer by its active three-dimensional shape, and its genotype by its primary sequence, we propose a model that predicts and characterizes the statistical distribution of a population of biopolymers with a specific phenotype, that originated from a given genotypic sequence by a single mutational event. Depending on the ratio g0 that characterizes the spread of potential energies of the mutated population with respect to temperature, three different statistical regimes have been identified. We suggest that biopolymers found in nature are in a critical regime with g0 in the range 1-6, corresponding to a broad, but not too broad, phenotypic distribution resembling a truncated Levy flight. Thus the biopolymer phenotype can be considerably modified in just a few mutations. The proposed model is in good agreement with the experimental distribution of activities determined for a population of single mutants of a group I ribozyme.Comment: to appear in Phys. Rev. E; 7 pages, 6 figures; longer discussion in VII, new fig.

Obesity Group Medical Visits

Background: Obesity is a major risk factor associated with multiple chronic diseases, presenting a significant global health challenge. Current evidence supports that group medical visits, an alternative format for the provision of primary care, are effective in disease management. Purpose: The goal of this project was to examine the effectiveness of group medical visits for the management of obesity in primary care. Methods: Individuals with a BMI greater than 30 participated in a series of six multidisciplinary group medical visits over a 12-week period. Each session included a brief individual medical visit followed by group education and discussion. Topics included; introduction and goal setting, behavior changes, nutrition, physical activity, challenges/struggles, and future goals. Results: Data was obtained pre and post 12 week group sessions from health records and from questionnaires. Nine individuals age 52 to 76, with a variety of chronic medical conditions in addition to obesity, participated. Following with 12-week group sessions, attendees, as a group had a decrease in weight (P=.006), BMI (P=.007) and waist circumference (P=.019). Participants and providers indicated high levels of satisfaction. All participants found that they were able to make better choices about general health, identified group visits as more helpful than individual healthy life style discussions, and would participate in this type of visit again. Conclusions: This collaborative model of care needs further evaluation with larger groups; however, the group medical visit appears to be a successful method for educating and supporting lifestyle modifications for individuals with obesity in this clinical setting

Volume fluctuations and geometrical constraints in granular packs

Structural organization and correlations are studied in very large packings of equally sized acrylic spheres, reconstructed in three-dimensions by means of X-ray computed tomography. A novel technique, devised to analyze correlations among more than two spheres, shows that the structural organization can be conveniently studied in terms of a space-filling packing of irregular tetrahedra. The study of the volume distribution of such tetrahedra reveals an exponential decay in the region of large volumes; a behavior that is in very good quantitative agreement with theoretical prediction. I argue that the system's structure can be described as constituted of two phases: 1) an `unconstrained' phase which freely shares the volume; 2) a `constrained' phase which assumes configurations accordingly with the geometrical constraints imposed by the condition of non-overlapping between spheres and mechanical stability. The granular system exploits heterogeneity maximizing freedom and entropy while constraining mechanical stability.Comment: 5 pages, 4 figure